Buprenophine Log

Generic name: Extended-release buprenorphine

Extended-release buprenorphine is an injectable formulation that uses in-situ gel forming technology to release buprenorphine at a controlled rate over a one-month period. It is injected by a treatment provider as a liquid and, once inside the body, turns to a solid gel called a depot. The depot gradually releases buprenorphine at a controlled rate, providing a constant blood level of drug throughout the month.

Mechanism of action
Buprenorphine is a mu-opioid receptor partial agonist and a kappa-opioid receptor antagonist.

Treatment of moderate to severe opioid use disorder

Dosage form and strengths
Prefilled syringe: 100 mg/0.5 mL and 300 mg/1.5 mL

Extended-release buprenorphine should be administered monthly only by subcutaneous injection in the abdominal region.