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LEUKINRA

Generic Name: Anakinra
Originator’s name: Kineret
LeukinRA is a recombinant, nonglycosylated form of the human interleukin-1 receptor antagonist (IL-1Ra). LeukinRA differs from native human IL-1Ra in that it has the addition of a single methionine residue at its amino terminus. LeukinRA consists of 153 amino acids and has a molecular weight of 17.3 kilodaltons. It is produced by recombinant DNA technology using an E coli bacterial expression system.

INDICATION

  • For the reduction in signs and symptoms
    and slowing the progression of structural
    damage in moderately to severely active
    rheumatoid arthritis (RA), in patients 18
    years of age or older who have failed 1 or
    more disease modifying antirheumatic
    drugs (DMARDs)
  • Can be used alone or in combination with
    DMARDs other than Tumor Necrosis
    Factor (TNF) blocking agents
  • For the treatment of Neonatal-Onset
    Multisystem Inflammatory Disease
    (NOMID)