Generic Name: Esomeprazole
Originator’s name: NEXIUM® I.V
Esomeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+ /K+ ¬ ATPase in the gastric parietal cell. Esomeprazole is the s-isomer of omeprazole. The S- and R-isomers of omeprazole are protonated and converted in the acidic compartment of the parietal cell forming the active inhibitor, the achiral sulphenamide. By acting specifically on the proton pump, Esomeprazole blocks the final step in acid production, thus reducing gastric acidity. This effect is dose-related up to a daily dose of 20 to 40mg and leads to inhibition of gastric acid secretion.


  • Gastro-oesophageal reflux disease (in the
    presence of erosive reflux oesophagitis)
  • Symptomatic treatment of gastrooesophageal
    reflux disease (in the
    absence of oesophagitis)
  • Severe peptic ulcer bleeding (following
    endoscopic treatment)
  • NSAID-associated gastric ulcer
  • Prophylaxis of NSAID-associated gastric
    or duodenal ulcer